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Diablo 4 Season 10 Lair Boss Farming Guide: Best Strategies For Mythic Uniques

Posted: Sep 28, 2025 Views: 38

Posted: Sep 28, 2025

Source:  IGGM

Views: 38

Diablo 4 Season 10 brought unprecedented joy to players, but this joy was short-lived. Active players reached the endgame content within 2-3 days and began farming for unique items and Chaos Armor to complete their builds.

In addition to Infernal Hordes and Chaos Rifts, Lair Bosses are also a main target for players every season. Due to changes to boss mechanics, the optimal strategy for farming bosses in Season 10 will also change.

Diablo 4 Season 10 Lair Boss Farming Guide: Best Strategies For Mythic Uniques

Lair Boss Mechanics Changes

Since the unique equipment pool from Infernal Hordes has been removed and integrated into the universal drop pool for all Lair bosses, each boss now has its own unique equipment drop list. Furthermore, the new unique equipment added in Season 10 requires farming specific bosses.

One of the most significant changes in Season 10 is that when a boss attempts to activate its shield and enter an invincible phase at a certain health point, the invincibility phase can be prevented if the player can destroy the shield within 5 seconds. This significantly improves the efficiency of farming Diablo 4 items from Lair Bosses.

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Lair Boss System

Lair Boss challenge mechanics remain unchanged; you can challenge them directly at the boss location for free. However, the chests that appear after defeating the boss require the corresponding summoning materials to open.

It is highly recommended to partner with your friends. Even though each team member must bring their own materials to open their own chests, a full group will increase the unique item amount .

Also, the chances of obtaining Mythic Unique items increase when challenging higher-level bosses and at higher-level Torment difficulties.

A special red skull-shaped door icon marks the boss location on the map. Hovering over it reveals details and allows for direct teleportation.

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The materials required for each Boss are as follows:

  • Varshan: 12x Malignant Hearts
  • Grigoire: 12x Living Steel
  • Lord Zir: 12x Exquisite Blood
  • Beast in the Ice: 12x Distilled Fear
  • Urvaar: 12x Judicator Masks
  • Duriel: 3x Shard of Agonies
  • Andariel: 3x Pincushion Dolls
  • Harbinger of Hatred: 3x Abhorrent Hearts
  • Belial, Lord of Lies: 2x Betrayer Husks
  • Bartuc (Infernal Hordes Boss): 666x Burning Aether Torment difficulty)
  • Astaroth (Nightmare Dungeon Boss): No materials required

How To Get Lair Boss Keys?

Malignant Heart: Whispers or Open World drops in Helltides

  • Living Steel: Helltides Chests
  • Distilled Fear: Nightmare Dungeons
  • Exquisite Blood: Elites in Legion Events, Helltides, and World Bosses
  • Judicator's Mask: Helltides, Whispers, and World Bosses
  • Shard of Agony: Varshan or Grigoire
  • Pincushioned Doll: Lord Zir or Beast in the Ice
  • Abhorrent Heart: Urivar
  • Betrayer's Husk: Belial's Ambush

In addition to farming boss materials, you'll also receive Stygian Stones after defeating bosses. These can be converted at The Alchemist into materials for any Great Boss: Shard of Agony, Pincushion Dolls, and Abhorrent Hearts. Note that they cannot be converted into Betrayer's Husk in Diablo IV.

These boss materials are also tradable. If you have enough Diablo IV gold, you can always obtain boss materials from other players.

Season 10 unique items drop from the following bosses:

  • Sabre of Tsasgal (Barbarian): Varshan
  • Kilt of Blackwing (Druid): The Beast in Ice
  • Gospel of the Devotee (Necromancer): Varshan and Urivar
  • Orphan Maker (Rogue): Lord Zir
  • Galvanic Azurite (Sorcerer): Andariel and Harbinger of Hatred
  • Hesha e Kesungi (Spiritborn): Grigoire and Urivar

In addition to their unique drops, each boss also has a new universal pool of unique gear. Each unique item in this pool has a chance of appearing in any boss's loot.

However, Belial is a bit different. After defeating Belial, players can freely choose from any other boss's pool as a reward. Belial also has the highest drop rate for Mythic unique items in the game. Therefore, consistently farming Belial and then selecting Duriel's drop pool to farm Duriel-exclusive gear, especially Mythic unique items, is the most efficient method.

Season 10 Farming Strategy

Since the invincibility phase can be skipped, the strategy for farming Mythic unique items has changed:

  • Tier S: Belial has the highest drop rate, but Diablo 4 Betrayer's Husk is very difficult to obtain.
  • Tier A: Duriel, Andariel, and Harbinger of Hatred. Mythic unique items have a good drop rate, but require high damage, so it's best to farm them in a group.
  • Tier B: Varshan, Grigoire, Lord Zir, Beast in the Ice, and Urvaar. These are relatively easy to farm solo.

The above is the gear and content that can be farmed for Lair Bosses in Season 10. Lair Bosses have always been a staple of farming, but the materials can be a challenge. We recommend farming boss materials in other activities first. Once you've accumulated enough Boss keys, team up with friends to farm for the highest efficiency.


Farming lair bosses is the primary way players obtain Mythic items, but Boss Materials are the biggest obstacle. Visit IGGM.com and Here will provide you with the fastest and best service, whether you want to buy Diablo 4 gold, boss keys, or Mythic unique items.

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