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Borderlands 4 Vivisecting Throwing Knife Farming Guide | Best Drop Locations, Stats & Boss-Melting Build Tips

Posted: Oct 04, 2025 Views: 54

As a shooter-adventure game, Borderlands 4 features a unique weapon component system, offering billions of guns, each with its own strengths, weaknesses, and special effects depending on its components and manufacturer.

Therefore, choosing the right weapon for each combat scenario is key to survival, especially on higher difficulty levels.

About Vivisecting Throwing Knife

Vivisecting Throwing Knife is a powerful Legendary weapon in Borderlands 4. It converts all damage you deal to your target into critical hits for a short period of time, significantly increasing your damage.

Vivisecting Throwing Knife is highly sought after for its Penetrator Augment, making it a key weapon for Vex Siren class, dealing infinite damage. When combined with Vex Siren's passive ability, it can stack bleed damage, continuously dealing critical hits to enemies and their other status effects, quickly melting bosses.

Not only that, but this knife is also very effective for other classes, as it can convert any damage into a critical hit, eliminating the need to use a specific critical hit skill.

This knife is an extremely rare purple drop, making it difficult to find. However, here we'll show you several viable ways to obtain the Vivisecting Throwing Knife and the best gameplay strategies for this legendary weapon, allowing you to fully utilize its power. So, let's get started.

Borderlands 4 Vivisecting Throwing Knife Farming Guide | Best Drop Locations, Stats & Boss-Melting Build Tips

How To Farm Vivisecting Throwing Knife?

The Pitted Stain Drill Site

First and foremost, the primary location for farming Vivisecting Throwing Knife is Pitted Stain Drill Site, located west of Fortress Indomita.

This location boasts a high enemy density and fast respawn rates, allowing you to quickly farm purple items. What's more, you can also obtain this legendary knife by defeating the three bosses within Drill Site.

However, please note that Vivisecting Throwing Knife is not a guaranteed drop from a specific boss. These bosses simply have a higher chance of dropping purple items than mobs.

If you're looking to eliminate a large number of enemies in a small area and get purple items, then the specific Drill Site at Pitted Stain is ideal for farming.

Splashzone Boss

However, there are several other locations in Borderlands 4 where you can also farm purple items. One of these is Splashzone boss in Riptide Grotto.

Splashzone is a boss fight during the main quest, Recruitment Drive. However, after completing that quest, Splashzone can be farmed again. Players simply return to the location and spend some Borderlands 4 money at Moxxi's Big Encore Machine near the boss arena entrance to respawn the boss.

Typically, it only takes about two seconds to kill Splashzone. If you have a friend, you can even farm purple items in co-op. Since the boss respawns instantly, you can farm as much as possible without slowing down the game, which is crucial for increasing your chances of dropping Vivisecting Throwing Knife and higher-quality weapons. Even if you're just playing solo, you can farm until the knife drops.

However, this farming process can be a bit tedious. If you're looking for a change of pace, you can also obtain Vivisecting Throwing Knife through the following method.

Red Chests

Alternatively, if you want to obtain the knife from Red Chests, you can start farming in the area near Vault Fragment in Stillshore, located in the lower left corner of the map. Red Chests typically have a higher chance of dropping purple and legendary items.

First, you must ensure that the nearby checkpoint or safe point is activated. Then, head to the locked chest and kill all enemies in the area, including any spawned Badass enemies. Once all enemies are defeated, Red Chest will unlock and can be looted.

The next key step is to pause the game and exit the main menu. Reloading the game will respawn at the activated checkpoint, with the enemies and Red Chest reset and ready for another round of looting.

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Bounty Board

There's actually a fourth way to unlock Vivisecting Throwing Knife.

If you want to quickly level up while farming, you can also visit Makeshift Chalet Bounty Board. However, you need to complete the game and unlock Ultimate Vault Hunter Mode before you can start taking on bounties.

Next, you need to go to Makeshift Chalet Safehouse and then look for a purple bounty on Bounty Board. If there isn't one, log out and log back in until you get one.

Bounties are usually located very close to Safehouse, and completing them is a great way to gain XP and level up quickly, especially Vile Bounties, which even have a chance to drop valuable Legendary-tier gear.

Why Is Vivisecting Throwing Knife So Important?

Now that you know how to get Vivisecting Throwing Knife, I want to quickly explain the theoretical purpose of this knife and why everyone is so eager to find it.

This is largely because of its Damage Amp Payload modifier, which increases the damage dealt to targets hit by 15% for 5 seconds. Furthermore, there's Penetrator Augment, which automatically critically impacts targets hit within 5 seconds.

Simply put, during these 5 seconds, you'll only critically affect enemies, meaning you'll absolutely destroy them regardless of your weapon. So, simply keep throwing your knife at your enemies and landing critical hits - you don't even have to aim for the head.

As a result, a build using Vivisecting Throwing Knife can melt even the most powerful final bosses in seconds, making the game incredibly easy for its users.

The knife's ability to critically impact all damage effectively bypasses Vault Hunter's critical hit abilities and perks, rendering them ineffective. More importantly, it provides an interesting and challenging way to deal damage, offering an immediate alternative to the slow-exploding grenades.

In short, the sheer power of Vivisecting Throwing Knife renders most other grenade or Ordnance options obsolete, as its rapid cooldown and immediate, massive damage potential completely outclass them.


So if you're planning a boss-killing build, this Legendary Knife is a must-have! If you don't want to be stuck in a farming cycle, you can also buy cheap and fast delivery Borderlands 4 Vivisecting Throwing Knife from IGGM.com and enjoy the thrill of melting bosses right away!

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