Diablo 4 Season 15 the Best Way to Farm Mythic Items Based on the New Enemies and Encounters
Posted: Sep 22, 2026
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Even with the introduction of crafting, Mythic items remain the rarest and most powerful gear in Diablo 4. In Season 15, the methods for obtaining them have shifted once again.
The good news is that, compared to the previous season, farming Mythics has become slightly more streamlined; powerful bosses now drop loot directly, eliminating the strict requirement to hoard Superior Lair Keys just to unlock their respective treasure hoards.
Below, we detail reliable and efficient methods for farming Mythic items in Season 15.

Achieve first kills on the three main bosses
To celebrate the franchise's 30th anniversary, Diablo 4 Season 15 introduces several new elements, including battles against three iconic main bosses: Mephisto, Baal, and Diablo.
Mephisto officially joined Diablo 4 via Lord of Hatred expansion, and his boss mechanics remain a key feature. As one of the most dangerous endgame bosses, securing a first kill against him in Season 15 guarantees a high-value Mythic item.
To claim this loot, you must be strong enough to defeat Mephisto and possess at least one Crux of the False Prophet to unlock his exclusive hoard.
The most efficient ways to farm this specific lair key in Season 15 are through War Plans rewards or by repeatedly completing Tree of Whispers bounties. However, since the drop is randomized, a bit of luck is involved.
For the other two main bosses, Baal and Diablo, defeating them once at specific difficulty levels (Torment 12 for Baal; Torment 8 for Diablo) grants you a Mythic item via seasonal progression rewards.
Naturally, these three boss fights are extremely challenging. If you hit a wall while trying to boost your character's power, consider choosing Diablo 4 items for sale to help you overcome the obstacles.
Make the most of Splinters of Evil
The addition of these three main bosses brings not only new combat encounters and loot but also significantly impacts other Diablo 4 endgame mechanics.
Defeating any of these bosses grants you a corresponding Splinter of Evil. Each splinter alters two specific endgame activities and collectively influences Tree of Whispers.
Regarding the acquisition of Mythic items, Splinter of Hatred obtained after killing Mephisto unlocks Resplendent Favor effect: if you earn a Resplendent Spark through a Tree of Whispers quest, the final yield is doubled.
While this scenario may not occur frequently, it remains highly valuable given that you will likely be completing Whispers quests throughout the season. With these Sparks, you can visit the blacksmith to craft two random Mythic Uniques or Iconic Mythics.
Splinter of Destruction, obtained after killing Baal, provides Colossal Foe effect, which gives Boss Ambush encounters a chance to spawn boss-level monsters.
When your splinter reaches Level 22 or higher, these boss monsters are guaranteed to drop Superior Lair Keys. This ensures you will obtain a high-tier lair key.
Once you have accumulated enough Superior Lair Keys, you can farm Belial, one of the lair bosses, and roll for Mythic items from his hoard.
Notably, opening lair boss hoards during Diablo 4 Season 15 carries a chance to trigger Nemesis Portals. Entering and completing these encounters offers a high probability of obtaining Mythics, and equipping Splinter of Destruction increases the spawn rate of these portals.
Defeating the three Prime Evils under specific conditions
Prime Evils refer to the three main bosses introduced in Season of Hell's Legacy. After defeating them in the main questline, they do not disappear permanently; once you unlock Torment 10 difficulty, you can challenge them again via the highest tier of Waking Nightmares.
Waking Nightmares is another signature mechanic introduced in Season 15, featuring three difficulty levels, with the hardest being Capstone.
Defeating any of the three Prime Evils within this special dungeon offers a very high chance of obtaining brand-new Uniques, Mythic Uniques, or Resplendent Sparks.

We particularly recommend focusing on farming Baal; the terrain in his area is straightforward and easy to navigate, resulting in higher overall farming efficiency.
Alternatively, while farming during endgame events affected by a specific Splinter of Evil, there is a random chance to trigger the corresponding Prime Evil.
A word of caution: you can only equip one of the three Splinters of Evil at a time. If you encounter a Prime Evil while wearing its corresponding splinter, you will be significantly weakened during the fight; therefore, be sure to switch splinters before engaging in targeted farming.
How to face all three Prime Evils at once?
Beyond individual encounters, Diablo 4 Season 15 features a hidden method that allows you to face all three Prime Evils simultaneously. While this battle is much more difficult, the drop rates for Mythic items and other rare loot are significantly higher.
This hidden encounter is known as Echo of Tristram. To unlock it, you must collect all three Splinters of Evil and combine them in Horadric Cube to create Wirt's Lucky Coin.
Next, collect ten copies of Deckard's Journal, speak to Deckard Cain to unlock a portal to Tristram, and interact with Fountain at Tristram to access the hidden Echo of Tristram area.

Among the available loot, Hellfire Torch is the rarest item. It provides massive boosts to your attributes, resistances, and skill levels, while also allowing you to equip an additional charm.
That covers everything for this guide. In Diablo 4 Season 15, Mythic items remain highly valuable, and the farming methods for them effectively integrate a mix of new and existing mechanics, so jump into the game and give them a try!
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